Distinct functions of antigen-specific CD4 T cells during murine Mycobacterium tuberculosis infection

@article{Reiley2010DistinctFO,
  title={Distinct functions of antigen-specific CD4 T cells during murine Mycobacterium tuberculosis infection},
  author={W. Reiley and S. Shafiani and S. Wittmer and G. Tucker-Heard and J. Moon and M. Jenkins and K. Urdahl and G. Winslow and D. Woodland},
  journal={Proceedings of the National Academy of Sciences},
  year={2010},
  volume={107},
  pages={19408 - 19413}
}
The immune response elicited after Mycobacterium tuberculosis (Mtb) infection is critically dependent on CD4 T cells during both acute and chronic infection. How CD4 T-cell responses are maintained throughout infection is not well understood, and evidence from other infection models has suggested that, under conditions of chronic antigen stimulation, T cells can undergo replicative exhaustion. These findings led us to determine whether subpopulations of CD4 T cells existed that displayed… Expand
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