Distinct functions of IRF-3 and IRF-7 in IFN-alpha gene regulation and control of anti-tumor activity in primary macrophages.

@article{Solis2006DistinctFO,
  title={Distinct functions of IRF-3 and IRF-7 in IFN-alpha gene regulation and control of anti-tumor activity in primary macrophages.},
  author={Mayra Solis and Delphine Goubau and Rapha{\"e}lle Romieu-Mourez and Pierre G{\'e}nin and Ahmet Civas and John Hiscott},
  journal={Biochemical pharmacology},
  year={2006},
  volume={72 11},
  pages={1469-76}
}
Type I IFN (IFN-alpha/beta) have important biological functions ranging from immune cell development and activation, to tumor cell killing and most importantly inhibition of virus replication. Following viral infection or activation of Toll-like receptors (TLRs) via distinct ligands, IFN-alpha/beta are produced. Two members of the interferon regulatory factor (IRF) family - IRF-3 and IRF-7 - are the major modulators of IFN gene expression. Activation of IRF-3 and IRF-7 by TBK1/IKKvarepsilon… CONTINUE READING
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