Distinct functions for Wnt/β-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis.

@article{Choi2013DistinctFF,
  title={Distinct functions for Wnt/$\beta$-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis.},
  author={Y. Choi and Yuhang Zhang and M. Xu and Y. Yang and Mayumi Ito and Tien Peng and Zheng Cui and A. Nagy and A. Hadjantonakis and R. Lang and G. Cotsarelis and T. Andl and E. Morrisey and S. Millar},
  journal={Cell stem cell},
  year={2013},
  volume={13 6},
  pages={
          720-33
        }
}
Wnt/β-catenin signaling is a central regulator of adult stem cells. Variable sensitivity of Wnt reporter transgenes, β-catenin's dual roles in adhesion and signaling, and hair follicle degradation and inflammation resulting from broad deletion of epithelial β-catenin have precluded clear understanding of Wnt/β-catenin's functions in adult skin stem cells. By inducibly deleting β-catenin globally in skin epithelia, only in hair follicle stem cells, or only in interfollicular epidermis and… Expand
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Wnt Signaling in Adult Epithelial Stem Cells and Cancer.
  • Si Hui Tan, N. Barker
  • Biology, Medicine
  • Progress in molecular biology and translational science
  • 2018
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