Distinct functions and cooperative interaction of the subunits of the transporter associated with antigen processing (TAP).

@article{Karttunen2001DistinctFA,
  title={Distinct functions and cooperative interaction of the subunits of the transporter associated with antigen processing (TAP).},
  author={Jaana T. Karttunen and Paul J Lehner and Saumya Shree Gupta and Eric W Hewitt and Peter Cresswell},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 13},
  pages={7431-6}
}
The ATP-binding cassette (ABC) transporter TAP translocates peptides from the cytosol to awaiting MHC class I molecules in the endoplasmic reticulum. TAP is made up of the TAP1 and TAP2 polypeptides, which each possess a nucleotide binding domain (NBD). However, the role of ATP in peptide binding and translocation is poorly understood. We present biochemical and functional evidence that the NBDs of TAP1 and TAP2 are non-equivalent. Photolabeling experiments with 8-azido-ATP demonstrate a… CONTINUE READING
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Model of early events in peptide transport by TAP

  • D. C. Gadsby, A. C. Nairn
  • Physiol. Rev. 79,
  • 1999

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