Distinct functional domains of neurofibromatosis type 1 regulate immediate versus long-term memory formation.

@article{Ho2007DistinctFD,
  title={Distinct functional domains of neurofibromatosis type 1 regulate immediate versus long-term memory formation.},
  author={Ivan Shun Ho and Frances Hannan and H F Guo and Inessa Hakker and Yi Zhong},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2007},
  volume={27 25},
  pages={6852-7}
}
Neurofibromatosis type 1 (NF1) is a dominant genetic disorder that causes tumors of the peripheral nervous system. In addition, >40% of afflicted children have learning difficulties. The NF1 protein contains a highly conserved GTPase-activating protein domain that inhibits Ras activity, and the C-terminal region regulates cAMP levels via G-protein-dependent activation of adenylyl cyclase. Behavioral analysis indicates that learning is disrupted in both Drosophila and mouse NF1 models. Our… CONTINUE READING
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