Distinct function of androgen receptor coactivator ARA70α and ARA70β in mammary gland development, and in breast cancer

@article{Wu2010DistinctFO,
  title={Distinct function of androgen receptor coactivator ARA70α and ARA70β in mammary gland development, and in breast cancer},
  author={Xinyu Wu and Erwei Song and Aysegul Sahin and Constance Albarracin and Zhiheng Pei and Xuanyi Zou and Baljit Singh and Ruliang Xu and G. P. Daniels and Yirong Li and Jianjun Wei and Marvin Blake and Robert J Schneider and Pamela Cowin and Peng Ng Ang Noi Lee},
  journal={Breast Cancer Research and Treatment},
  year={2010},
  volume={128},
  pages={391-400}
}
Steroid receptor coactivators are important in regulating the function of the receptors in endocrine organ development and in cancers, including breast. Androgen receptor (AR) coactivator ARA70, was first identified as a gene fused to the ret oncogene and later characterized as an AR coactivator. We previously reported that the full length ARA70α functions as a tumor suppressor gene and that ARA70β functions as an oncogene in prostate cancer. Here we show that both ARA70α and ARA70β function as… CONTINUE READING