Distinct focal adhesion protein modules control different aspects of mechanotransduction.

  title={Distinct focal adhesion protein modules control different aspects of mechanotransduction.},
  author={Ben Stutchbury and Paul Atherton and Ricky Tsang and De-Yao Wang and Christoph Ballestrem},
  journal={Journal of cell science},
  volume={130 9},
Focal adhesions (FAs) are macromolecular complexes that regulate cell adhesion and mechanotransduction. By performing fluorescence recovery after photobleaching (FRAP) and fluorescence loss after photoactivation (FLAP) experiments, we found that the mobility of core FA proteins correlates with their function. Structural proteins such as tensin, talin and vinculin are significantly less mobile in FAs than signaling proteins such as FAK (also known as PTK2) and paxillin. The mobilities of the… CONTINUE READING
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