Distinct features of multivesicular body-lysosome fusion revealed by a new cell-free content-mixing assay.

Abstract

When marked for degradation, surface receptor and transporter proteins are internalized and delivered to endosomes where they are packaged into intralumenal vesicles (ILVs). Many rounds of ILV formation create multivesicular bodies (MVBs) that fuse with lysosomes exposing ILVs to hydrolases for catabolism. Despite being critical for protein degradation, the… (More)
DOI: 10.1111/tra.12543

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Cite this paper

@article{Karim2018DistinctFO, title={Distinct features of multivesicular body-lysosome fusion revealed by a new cell-free content-mixing assay.}, author={Mahmoud Abdul Karim and Dieter R Samyn and Sevan Mattie and Christopher Leonard Brett}, journal={Traffic}, year={2018}, volume={19 2}, pages={138-149} }