Distinct factors regulate the murine RAG-2 promoter in B- and T-cell lines.

  title={Distinct factors regulate the murine RAG-2 promoter in B- and T-cell lines.},
  author={Josh D Lauring and Mark S Schlissel},
  journal={Molecular and cellular biology},
  volume={19 4},
The recombination activating genes RAG-1 and RAG-2 are expressed in a lymphoid-cell-specific and developmentally regulated fashion. To understand the transcriptional basis for this regulation, we have cloned and characterized the murine RAG-2 promoter. The promoter was lymphoid cell specific, showing activity in various B- and T-cell lines but little activity in nonlymphoid cells. To our surprise, however, the promoter was regulated differently in B and T cells. Using nuclear extracts from B… CONTINUE READING


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