Distinct expression patterns of glycoprotein hormone-alpha2 and -beta5 in a basal chordate suggest independent developmental functions.

@article{Santos2009DistinctEP,
  title={Distinct expression patterns of glycoprotein hormone-alpha2 and -beta5 in a basal chordate suggest independent developmental functions.},
  author={Sandra Christo dos Santos and Claire Bardet and St{\'e}phanie Bertrand and H{\'e}ctor Escriv{\`a} and Damien Habert and Bruno Qu{\'e}rat},
  journal={Endocrinology},
  year={2009},
  volume={150 8},
  pages={3815-22}
}
The vertebrate glycoprotein hormones (GpHs), gonadotropins and thyrotropin, are heterodimers composed of a common alpha- and specific beta-subunit. The recombinant heterodimer of two additional, structurally related proteins identified in vertebrate and protostome genomes, the glycoproteins-alpha2 (GPA2) and-beta5 (GPB5), was shown to activate the… CONTINUE READING