Distinct expression patterns of claudin-1 and claudin-4 in intraductal papillary-mucinous tumors of the pancreas.

@article{Tsukahara2005DistinctEP,
  title={Distinct expression patterns of claudin-1 and claudin-4 in intraductal papillary-mucinous tumors of the pancreas.},
  author={Munetoshi Tsukahara and Hideo Nagai and Tomoko Kamiakito and Hirotoshi Kawata and Norio Takayashiki and Ken Saito and Akira Tanaka},
  journal={Pathology international},
  year={2005},
  volume={55 2},
  pages={63-9}
}
The expression of claudin-4 was investigated in human pancreas, pancreatic ductal adenocarcinomas, and intraductal papillary-mucinous tumors of the pancreas (IPMT), and compared with that of claudin-1. In human adult pancreatic specimens, both claudin-1 and claudin-4 were immunohistochemically found in main and branching pancreatic ducts, terminal ductules and acinic cells, with the exception of endocrine cells. Of 12 cases of pancreatic ductal adenocarcinoma, 11 (92%) had positive… CONTINUE READING
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