Distinct expression of cold receptors (TRPM8 and TRPA1) in the rat nodose-petrosal ganglion complex.

@article{Hondoh2010DistinctEO,
  title={Distinct expression of cold receptors (TRPM8 and TRPA1) in the rat nodose-petrosal ganglion complex.},
  author={Aki Hondoh and Yusuke Ishida and Shinya Ugawa and Takashi Ueda and Yasuhiro Shibata and Takahiro Yamada and Michiko Shikano and Shingo Murakami and Shoichi Shimada},
  journal={Brain research},
  year={2010},
  volume={1319},
  pages={60-9}
}
TRPM8 and TRPA1 are cold-activated transient receptor potential (TRP) cation channels. TRPM8 is activated by moderate cooling, while TRPA1 is activated by extreme, noxious cold temperatures. These cold receptors are expressed in different subpopulations of primary afferent neurons. TRPA1 is co-expressed in a subpopulation of somatosensory neurons expressing TRPV1, which is activated by heat. However, the distribution and co-expression of these channels in the nodose-petrosal ganglion complex… CONTINUE READING