Distinct expression and distribution of vesicular proteins in the hippocampus of TNFa-deficient mice during development.

Tumor necrosis factor alpha (TNFa) is a cytokine produced mainly by cells of the immune system. It is also expressed by brain neurons and glia. In the brain, TNFa governs synaptic plasticity, such as long-term potentiation and learning. Using TNFa-deficient mice (TNFa-KO) and immunohistochemical techniques, we resolved the spatio-temporal effect of TNFa on… (More)