Distinct epitopes of Ik gene products identified by monoclonal antibodies.

@article{Pierres1980DistinctEO,
  title={Distinct epitopes of Ik gene products identified by monoclonal antibodies.},
  author={Michel Pierres and François M. Kourilsky and J P Rebouah and Magali Dosseto and Danielle H. Caillol},
  journal={European journal of immunology},
  year={1980},
  volume={10 12},
  pages={950-7}
}
Analysis of reactivity of monoclonal anti-Iak alloantibodies, obtained by fusion between NS 1 myeloma and spleen cells from alloimmune A. TH mice, permitted the identification of 9 distinct determinants of the Ik gene products. Competitive binding experiments indicated that 2 private epitopes (defined by H8-109.13 and H8-138.4 antibodies) of the I-Ak product could be separated, thereby apparently splitting the Ia.2 specificity. A public determinant of the I-Ak molecule (identified by H8-15.9… CONTINUE READING