Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo

@inproceedings{Gilsbach2017DistinctEP,
  title={Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo},
  author={Ralf Gilsbach and Martin Schwaderer and Sebastian Preissl and Bj{\"o}rn A. Gr{\"u}ning and David K. Kranzh{\"o}fer and Pedro Schneider and Thomas G N{\"u}hrenberg and Sonia Mulero-Navarro and Dieter Weichenhan and Christian Joerg Braun and Martina Dressen and Adam R. Jacobs and Harald Lahm and Torsten Doenst and Rolf Backofen and Markus Krane and Bruce D Gelb and Lutz Hein},
  booktitle={Nature Communications},
  year={2017}
}
Epigenetic mechanisms and transcription factor networks essential for differentiation of cardiac myocytes have been uncovered. However, reshaping of the epigenome of these terminally differentiated cells during fetal development, postnatal maturation, and in disease remains unknown. Here, we investigate the dynamics of the cardiac myocyte epigenome during development and in chronic heart failure. We find that prenatal development and postnatal maturation are characterized by a cooperation of… CONTINUE READING
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