Distinct enhancers of ptf1a mediate specification and expansion of ventral pancreas in zebrafish.

@article{Pashos2013DistinctEO,
  title={Distinct enhancers of ptf1a mediate specification and expansion of ventral pancreas in zebrafish.},
  author={Evanthia E. Pashos and Joon Tae Park and Steven T Leach and Shannon J. Fisher},
  journal={Developmental biology},
  year={2013},
  volume={381 2},
  pages={471-81}
}
Development of the pancreas and cerebellum require Pancreas-specific transcription factor-1a (Ptf1a), which encodes a subunit of the transcription factor complex PTF1. Ptf1a is required in succession for specification of the pancreas, proper allocation of pancreatic progenitors to endocrine and exocrine fates, and the production of digestive enzymes from the exocrine acini. In several neuronal structures, including the cerebellum, hindbrain, retina and spinal cord, Ptf1a is transiently… CONTINUE READING
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