Distinct efficacies for two endogenous ligands on a single cognate gonadoliberin receptor.

@article{Tensen1997DistinctEF,
  title={Distinct efficacies for two endogenous ligands on a single cognate gonadoliberin receptor.},
  author={Cornelis P. Tensen and Koichi Okuzawa and Marion Blomenr{\"o}hr and F Rebers and Rob Leurs and Jan Bogerd and R{\"u}diger Winfried Schulz and Henk J Th Goos},
  journal={European journal of biochemistry},
  year={1997},
  volume={243 1-2},
  pages={134-40}
}
A cDNA encoding a putative gonadoliberin receptor was cloned from the pituitary of the African catfish. Conceptual translation predicts a protein of 379 amino acids which shows typical characteristics of GTP-binding-protein-coupled receptors. The isolated cDNA was stable expressed in human embryonic kidney (HEK) 293 cells which were used for studies on gonadoliberin-activated second messenger systems (inositol phosphate production; increase in cAMP and/or intracellular Ca2+). The isolated cDNA… CONTINUE READING
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