Distinct effects of tissue-type plasminogen activator and SMTP-7 on cerebrovascular inflammation following thrombolytic reperfusion.

@article{Miyazaki2011DistinctEO,
  title={Distinct effects of tissue-type plasminogen activator and SMTP-7 on cerebrovascular inflammation following thrombolytic reperfusion.},
  author={Takuro Miyazaki and Yuji Kimura and Hisayuki Ohata and Terumasa Hashimoto and Keita Shibata and Keiji Hasumi and Kazuo Honda},
  journal={Stroke},
  year={2011},
  volume={42 4},
  pages={1097-104}
}
BACKGROUND AND PURPOSE Thrombolysis therapy using tissue-type plasminogen activator (t-PA) is occasionally accompanied by harmful outcomes, including intracerebral hemorrhage. We have reported that Stachybotrys microspora triprenyl phenol-7 (SMTP-7), a candidate thrombolytic drug, has excellent therapeutic effect on cerebral infarction in embolic stroke model in mice; however, little is known regarding whether this agent influences cerebrovascular inflammation following thrombolytic reperfusion… CONTINUE READING
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