Distinct effects of pravastatin, atorvastatin, and simvastatin on insulin secretion from a beta-cell line, MIN6 cells.

@article{Ishikawa2006DistinctEO,
  title={Distinct effects of pravastatin, atorvastatin, and simvastatin on insulin secretion from a beta-cell line, MIN6 cells.},
  author={Mayumi Ishikawa and Fuminori Okajima and Noriyuki Inoue and Kaori Motomura and Toyonori Kato and Akimitsu Takahashi and Shinichi Oikawa and Nobuhiro Yamada and Hitoshi Shimano},
  journal={Journal of atherosclerosis and thrombosis},
  year={2006},
  volume={13 6},
  pages={329-35}
}
In addition to the prevention of cardiovascular diseases by lowering plasma LDL cholesterol, recent studies suggest that statins could have some impact on insulin action. To estimate the direct effects of statins on insulin secretion from pancreatic beta-cells, MIN6 cells were treated with pravastatin, simvastatin, or atorvastatin. Basal insulin secretion at low glucose concentration was unexpectedly increased at very high doses of simvastatin or atorvastatin after 24- and 48-hour incubation… CONTINUE READING