Distinct effects of bFGF and PDGF on oligodendrocyte progenitor cells.

  title={Distinct effects of bFGF and PDGF on oligodendrocyte progenitor cells.},
  author={Randall D Mckinnon and Clay Smith and Toby N Behar and Trevor H. Smith and Monique Dubois-Dalcq},
  volume={7 3},
We have compared the effects of platelet-derived (PDGF) and basic fibroblast (bFGF) growth factors on the shape, migration, and differentiation of oligodendrocyte progenitor cells, the precursors of myelin-forming cells in the CNS. In the presence of bFGF, oligodendrocyte progenitors purified from rat neonatal brain cultures were stellate, non-motile, and had a morphological complexity of 1.26 +/- 0.03 as measured by fractal dimension (D). These cells expressed transcripts encoding the POU… CONTINUE READING


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