Distinct effects of acute and chronic nicotine application on microvascular thrombus formation and endothelial function in male and female mice

@article{Lindenblatt2007DistinctEO,
  title={Distinct effects of acute and chronic nicotine application on microvascular thrombus formation and endothelial function in male and female mice},
  author={Nicole Lindenblatt and Uwe Platz and J{\"o}rn Hameister and Ernst Klar and Michael Dieter Menger and Brigitte Vollmar},
  journal={Langenbeck's Archives of Surgery},
  year={2007},
  volume={392},
  pages={285-295}
}
Cigarette smoking is linked to thromboembolic events; however, a relationship between nicotine exposition and thrombosis has not been established. Thus, we intended to study the effect of acute and chronic nicotine application in an in vivo mouse model. In microvessels of the dorsal skin fold chamber, light-dye-induced thrombus formation was analyzed using intravital fluorescence microscopy. Male and female C57BL/6J mice received nicotine chronically via the drinking water (100 μg/ml) for 8… CONTINUE READING
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