Distinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma cells

@inproceedings{Yoshioka2017DistinctEO,
  title={Distinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma cells},
  author={Masahiro Yoshioka and Shinya Ohashi and Tomomi Ida and Yukie Nakai and Osamu Kikuchi and Yusuke Amanuma and Junichi Matsubara and Atsushi Yamada and Shin’ichi Miyamoto and Mitsuteru Natsuizaka and Hiroshi Nakagawa and Tsutomu Chiba and Hiroshi Seno and Manabu Muto},
  booktitle={Journal of experimental & clinical cancer research : CR},
  year={2017}
}
BACKGROUND Epidermal growth factor receptor (EGFR) plays a pivotal role in the pathophysiology of esophageal squamous cell carcinoma (ESCC). However, the clinical effects of EGFR inhibitors on ESCC are controversial. This study sought to identify the factors determining the therapeutic efficacy of EGFR inhibitors in ESCC cells. METHODS Immortalized-human… CONTINUE READING