Distinct effects of DNA-PKcs and Artemis inactivation on signal joint formation in vivo.

@article{Touvrey2008DistinctEO,
  title={Distinct effects of DNA-PKcs and Artemis inactivation on signal joint formation in vivo.},
  author={C{\'e}dric Touvrey and Chrystelle Couedel and Pauline Soulas and Rachel Couderc and Maria Jasin and Jean-Pierre de Villartay and Patrice N Marche and Evelyne Jouvin-Marche and Serge M Cand{\'e}ias},
  journal={Molecular immunology},
  year={2008},
  volume={45 12},
  pages={
          3383-91
        }
}
The assembly of functional immune receptor genes via V(D)J recombination in developing lymphocytes generates DNA double-stranded breaks intermediates that are repaired by non-homologous end joining (NHEJ). This repair pathway requires the sequential recruitment and activation onto coding and signal DNA ends of several proteins, including the DNA-dependent protein kinase and the nuclease Artemis. Artemis activity, triggered by the DNA-dependent protein kinase, is necessary to process the genes… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 60 references

The role of the non-homologous end-joining pathway in lymphocyte development

S. Rooney, J. Chaudhuri, F W.Alt
Immunol Rev • 2004
View 5 Excerpts
Highly Influenced

Linking double-stranded DNA breaks to the recombination activating gene complex directs repair to the nonhomologous end-joining pathway.

Proceedings of the National Academy of Sciences of the United States of America • 2007
View 4 Excerpts
Highly Influenced

Reassignment of the murine 3'TRDD1 recombination signal sequence

C. Touvrey, L G.Cowell, +3 authors S M.Candeias
Immunogenetics • 2006
View 9 Excerpts
Highly Influenced