Distinct effects of DNA-PKcs and Artemis inactivation on signal joint formation in vivo.

  title={Distinct effects of DNA-PKcs and Artemis inactivation on signal joint formation in vivo.},
  author={C{\'e}dric Touvrey and Chrystelle Couedel and Pauline Soulas and Rachel Couderc and Maria Jasin and Jean-Pierre de Villartay and Patrice N Marche and Evelyne Jouvin-Marche and Serge M Cand{\'e}ias},
  journal={Molecular immunology},
  volume={45 12},
The assembly of functional immune receptor genes via V(D)J recombination in developing lymphocytes generates DNA double-stranded breaks intermediates that are repaired by non-homologous end joining (NHEJ). This repair pathway requires the sequential recruitment and activation onto coding and signal DNA ends of several proteins, including the DNA-dependent protein kinase and the nuclease Artemis. Artemis activity, triggered by the DNA-dependent protein kinase, is necessary to process the genes… CONTINUE READING


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