Distinct driver mutation profiles of childhood and adolescent essential thrombocythemia.

To the Editor: The incidence of the Philadelphia chromosomenegative myeloproliferative neoplasms (MPN), polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF) is significantly lower in children than in adults with the most commonly acquired molecular drivers, JAK2 V617F and myeloproliferative leukemia (MPL) exon 10 mutations… CONTINUE READING