Distinct dopaminergic control of the direct and indirect pathways in reward-based and avoidance learning behaviors

@article{Nakanishi2014DistinctDC,
  title={Distinct dopaminergic control of the direct and indirect pathways in reward-based and avoidance learning behaviors},
  author={S. Nakanishi and Takatoshi Hikida and Satoshi Yawata},
  journal={Neuroscience},
  year={2014},
  volume={282},
  pages={49-59}
}
The nucleus accumbens (NAc) plays a pivotal role in reward and aversive learning and learning flexibility. Outputs of the NAc are transmitted through two parallel routes termed the direct and indirect pathways and controlled by the dopamine (DA) neurotransmitter. To explore how reward-based and avoidance learning is controlled in the NAc of the mouse, we developed the reversible neurotransmission-blocking (RNB) technique, in which transmission of each pathway could be selectively and reversibly… 
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