Distinct domains of the RelA NF-kappaB subunit are required for negative cross-talk and direct interaction with the glucocorticoid receptor.

@article{Wissink1997DistinctDO,
  title={Distinct domains of the RelA NF-kappaB subunit are required for negative cross-talk and direct interaction with the glucocorticoid receptor.},
  author={Sacha Wissink and E C van Heerde and Michael Schmitz and Eric Kalkhoven and Bart van der Burg and Patrick A. Baeuerle and Paul T. van der Saag},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 35},
  pages={22278-84}
}
The RelA subunit of NF-kappaB and the glucocorticoid receptor mutually repress each others transcriptional activity, thus providing a mechanism for immunosuppression. Deletion analysis of the glucocorticoid receptor has shown that the DNA binding domain and the ligand binding domain are essential components for repression. Here, we show by deletions and point mutations that both the Rel homology domain and the transactivation domains of RelA are required for repression of the transcriptional… CONTINUE READING

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