Distinct domains of complexins bind SNARE complexes and clamp fusion in vitro.

@article{Giraudo2008DistinctDO,
  title={Distinct domains of complexins bind SNARE complexes and clamp fusion in vitro.},
  author={Claudio G Giraudo and Alejandro Garcia-Diaz and William S. Eng and Ai Yamamoto and Thomas J. Melia and James E Rothman},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 30},
  pages={21211-9}
}
In regulated exocytosis, the core membrane fusion machinery proteins, the SNARE proteins, are assisted by a group of regulatory factors in order to couple membrane fusion to an increase of intracellular calcium ion (Ca(2+)) concentration. Complexin-I and synaptotagmin-I have been shown to be key elements for this tightly regulated process. Many studies… CONTINUE READING