Distinct determinants on collagen support alpha 2 beta 1 integrin-mediated platelet adhesion and platelet activation.

@article{Santoro1991DistinctDO,
  title={Distinct determinants on collagen support alpha 2 beta 1 integrin-mediated platelet adhesion and platelet activation.},
  author={Samuel A. Santoro and John J. Walsh and William D. Staatz and Karen J. Baranski},
  journal={Cell regulation},
  year={1991},
  volume={2 11},
  pages={
          905-13
        }
}
Recent studies have revealed that the sequence of amino acids asp-gly-glu-ala represents an essential determinant of the site within the alpha 1(I)-CB3 fragment of collagen recognized by the alpha 2 beta 1 integrin cell surface collagen receptor (Staatz et al., 1991). Studies employing chemical modifications of collagen amino acid side chains confirm both the essential nature of the acidic side chains of aspartic acid and glutamic acid residues and the nonessentiality of lysine epsilon-amino… CONTINUE READING

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