Distinct conformations of vitamin D receptor/retinoid X receptor-alpha heterodimers are specified by dinucleotide differences in the vitamin D-responsive elements of the osteocalcin and osteopontin genes.

@article{Staal1996DistinctCO,
  title={Distinct conformations of vitamin D receptor/retinoid X receptor-alpha heterodimers are specified by dinucleotide differences in the vitamin D-responsive elements of the osteocalcin and osteopontin genes.},
  author={Ada Staal and Andre J van Wijnen and Jan C. Birkenh{\"a}ger and Huibert A. P. Pols and Jean M. Prahl and Hector F DeLuca and Marie Pierre Gaub and Jane B Lian and Gary S Stein and Johannes P T M van Leeuwen and Janet L Stein},
  journal={Molecular endocrinology},
  year={1996},
  volume={10 11},
  pages={1444-56}
}
The 1 alpha,25-dihydroxyvitamin D3 (VD3)-dependent stimulation of osteocalcin (OC) and osteopontin (OP) gene transcription in bone tissue is mediated by interactions of trans-activating factors with distinct VD3-responsive elements (VDREs). Sequence variation between the OC- and OP-VDRE steroid hormone half-elements provides the potential for recognition by distinct hormone receptor homo- and heterodimers. However, the exact composition of endogenous VD3- induced complexes recognizing the OC… CONTINUE READING
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