Distinct cognitive effects and underlying transcriptome changes upon inhibition of individual miRNAs in hippocampal neurons.

@article{Malmevik2016DistinctCE,
  title={Distinct cognitive effects and underlying transcriptome changes upon inhibition of individual miRNAs in hippocampal neurons.},
  author={Josephine Malmevik and Rebecca Petri and Pina Knauff and Per Ludvik Bratt{\aa}s and Malin {\AA}kerblom and Johan Jakobsson},
  journal={Scientific reports},
  year={2016},
  volume={6},
  pages={19879}
}
MicroRNAs (miRNA) are small, non-coding RNAs mediating post-transcriptional regulation of gene expression. miRNAs have recently been implicated in hippocampus-dependent functions such as learning and memory, although the roles of individual miRNAs in these processes remain largely unknown. Here, we achieved stable inhibition using AAV-delivered miRNA… CONTINUE READING