Distinct clinicopathological features of NAB2-STAT6 fusion gene variants in solitary fibrous tumor with emphasis on the acquisition of highly malignant potential.

@article{Akaike2015DistinctCF,
  title={Distinct clinicopathological features of NAB2-STAT6 fusion gene variants in solitary fibrous tumor with emphasis on the acquisition of highly malignant potential.},
  author={Keisuke Akaike and Aiko Kurisaki-Arakawa and Kieko Hara and Yoshiyuki Suehara and Tatsuya Takagi and Keiko Mitani and Kazuo Kaneko and Takashi Yao and Tsuyoshi Saito},
  journal={Human pathology},
  year={2015},
  volume={46 3},
  pages={347-56}
}
The impact of NGFI-A binding protein 2 (NAB2)-signal transducer and activator of transcription 6 (STAT6) fusion on the biological behavior and the mechanism of acquisition of malignant phenotype in solitary fibrous tumor (SFT) is not well understood. We examined variations of the NAB2-STAT6 fusion gene in 40 cases of SFT using formalin-fixed, paraffin-embedded tissues and secondary genetic alterations of tumor protein p53 (TP53),, platelet-derived growth factor receptor, β polypeptide (PDGFRB… CONTINUE READING
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