Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer

  title={Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer},
  author={Scott Arthur Tomlins and Bharathi Laxman and Saravana M. Dhanasekaran and Beth E. Helgeson and Xuhong Cao and David Stuart Morris and A Haritha Menon and Xiaojun Jing and Qi Cao and Bo Han and Jindan Yu and Lei Wang and James E. Montie and Mark A. Rubin and Kenneth J. Pienta and Diane Roulston and Rajal B Shah and Sooryanarayana Varambally and Rohit Mehra and Arul M. Chinnaiyan},
Recently, we identified recurrent gene fusions involving the 5′ untranslated region of the androgen-regulated gene TMPRSS2 and the ETS (E26 transformation-specific) family genes ERG, ETV1 or ETV4 in most prostate cancers. Whereas TMPRSS2–ERG fusions are predominant, fewer TMPRSS2–ETV1 cases have been identified than expected on the basis of the frequency of high (outlier) expression of ETV1 (refs 3–13). Here we explore the mechanism of ETV1 outlier expression in human prostate tumours and… CONTINUE READING
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