Distinct circular dichroism spectroscopic signatures of polyproline II and unordered secondary structures: applications in secondary structure analyses.

@article{Lopes2014DistinctCD,
  title={Distinct circular dichroism spectroscopic signatures of polyproline II and unordered secondary structures: applications in secondary structure analyses.},
  author={Jose L S Lopes and Andrew J. Miles and Lee Whitmore and B. A. Wallace},
  journal={Protein science : a publication of the Protein Society},
  year={2014},
  volume={23 12},
  pages={1765-72}
}
Circular dichroism (CD) spectroscopy is a valuable method for defining canonical secondary structure contents of proteins based on empirically-defined spectroscopic signatures derived from proteins with known three-dimensional structures. Many proteins identified as being "Intrinsically Disordered Proteins" have a significant amount of their structure that is neither sheet, helix, nor turn; this type of structure is often classified by CD as "other", "random coil", "unordered", or "disordered… CONTINUE READING