Distinct changes in the laminin composition of basement membranes in human seminiferous tubules during development and degeneration.

@article{Virtanen1997DistinctCI,
  title={Distinct changes in the laminin composition of basement membranes in human seminiferous tubules during development and degeneration.},
  author={Ismo Virtanen and Jouni J Lohi and Takashi Tani and Matti Korhonen and Robert E. Burgeson and V. P. Lehto and Ilmo Leivo},
  journal={The American journal of pathology},
  year={1997},
  volume={150 4},
  pages={1421-31}
}
We studied the distribution of laminin (Ln) chains and their integrin (Int) receptors in normal developing and adult and in atrophied human testes by using immunohistochemistry. Immunostaining for EHS Ln and type IV collagen was used to identify basement membranes (BMs). In the BM of seminiferous epithelium of fetal testis, a panel of monoclonal antibodies showed immunoreactivity for Ln alpha 1-, alpha 2-, beta 1-, beta 2- and gamma 1-chains, suggestive of the presence of Lns 1 to 3. In BM of… CONTINUE READING

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