Distinct changes in morphometric networks in aging versus Alzheimer's disease dementia

@inproceedings{Binette2019DistinctCI,
  title={Distinct changes in morphometric networks in aging versus Alzheimer's disease dementia},
  author={Alexa Pichet Binette and Julie Gonneaud and Jacob W Vogel and Renaud La Joie and Pedro Rosa-Neto and Louis W. Collins and Judes Poirier and John C. S. Breitner and Sylvie Villeneuve and Etienne Vachon-Presseau and Alzheimer's Disease Neuroimaging Initiative},
  year={2019}
}
It remains unclear which grey matter (GM) changes are associated with Alzheimer9s disease (AD), and how these changes might differ from normal brain aging. Using independent component analysis of GM maps on a large, multi-cohort dataset, we derived morphometric networks and investigated GM volume in such networks in young, old adulthood, and AD. GM loss in frontal networks was more specific to aging, while it was the result of an additive effect of aging and AD in all other networks. The… CONTINUE READING
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