Distinct cell types control lymphoid subset development by means of IL-15 and IL-15 receptor alpha expression.

@article{Schluns2004DistinctCT,
  title={Distinct cell types control lymphoid subset development by means of IL-15 and IL-15 receptor alpha expression.},
  author={Kimberly S. Schluns and Elizabeth C. Nowak and Arturo Cabrera-Hern{\'a}ndez and Lynn Puddington and Leo Lefrançois and Hector Leonardo Aguila},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 15},
  pages={5616-21}
}
IL-15 and the IL-15 receptor (IL-15R)alpha chain are essential for normal development of naive CD8 T cells, intestinal intraepithelial lymphocytes (IEL), and natural killer (NK)/NK/T cells. However, whether IL-15R alpha expression by these subsets is necessary for their production and which cell type needs to produce IL-15 to drive development are unknown. We analyzed the requirements for IL-15 and IL-15R alpha expression by bone marrow-derived or parenchymal cells for mediating lymphocyte… CONTINUE READING

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