Distinct caspase pathways mediate necrosis and apoptosis in subpopulations of hippocampal neurons after status epilepticus.

@article{LopezMeraz2010DistinctCP,
  title={Distinct caspase pathways mediate necrosis and apoptosis in subpopulations of hippocampal neurons after status epilepticus.},
  author={Maria-Leonor Lopez-Meraz and Jer{\^o}me Niquet and Claude Guy Wasterlain},
  journal={Epilepsia},
  year={2010},
  volume={51 Suppl 3},
  pages={56-60}
}
Status epilepticus in the immature brain induces neuronal injury in the hippocampal formation, but the mode and mechanism of death are poorly understood. Our laboratory has recently investigated the role of caspase-3, -8, and -9 in neuronal injury, using a lithium-pilocarpine model of status epilepticus in 2-week-old rat pups. Our results showed that dying neurons in the dentate gyrus and CA1-subiculum area do not share the same mechanism of death. In CA1-subiculum, caspase-8 upregulation… CONTINUE READING

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