Distinct cagA EPIYA motifs are associated with ethnic diversity in Malaysia and Singapore.

@article{Schmidt2009DistinctCE,
  title={Distinct cagA EPIYA motifs are associated with ethnic diversity in Malaysia and Singapore.},
  author={Heather-Marie A Schmidt and Khean-lee Goh and K M Fock and Ida Hilmi and Subbiah Dhamodaran and David Forman and Hazel Mitchell},
  journal={Helicobacter},
  year={2009},
  volume={14 4},
  pages={256-63}
}
BACKGROUND In vitro studies have shown that the biologic activity of CagA is influenced by the number and class of EPIYA motifs present in its variable region as these motifs correspond to the CagA phosphorylation sites. It has been hypothesized that strains possessing specific combinations of these motifs may be responsible for gastric cancer development. This study investigated the prevalence of cagA and the EPIYA motifs with regard to number, class, and patterns in strains from the three… CONTINUE READING

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