Distinct bone marrow-derived and tissue resident macrophage-lineages proliferate at key stages during inflammation

Abstract

The general paradigm is that monocytes are recruited to sites of inflammation and terminally differentiate into macrophages. There has been no demonstration of proliferation of peripherally-derived inflammatory macrophages under physiological conditions. Here we show that proliferation of both bone marrow-derived inflammatory and tissue-resident macrophage… (More)
DOI: 10.1038/ncomms2877

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6 Figures and Tables