Distinct biological properties of two RET isoforms activated by MEN 2A and MEN 2B mutations

@article{Rossel1997DistinctBP,
  title={Distinct biological properties of two RET isoforms activated by MEN 2A and MEN 2B mutations},
  author={Mireille Rossel and Andrea Pasini and Sophie Chappius and Oliver Geneste and Laurence Fournier and Isabelle Schuffenecker and Masahide Takahishi and Leo Adrianus van Grunsven and Jos{\'e} Luis Urdiales and Brain B Rudkin and Gilbert M. Lenoir and Marc Billaud},
  journal={Oncogene},
  year={1997},
  volume={14},
  pages={265-275}
}
Germline mutations of the RET proto-oncogene, which codes for a receptor tyrosine kinase, cause multiple endocrine neoplasia type 2A (MEN 2A) and 2B (MEN 2B) and familial medullary thyroid carcinoma (FMTC). MEN 2 mutations have been shown to result in RET oncogenic activation. The RET gene encodes several isoforms whose biological properties, when altered by MEN 2 mutations, have not been thoroughly addressed yet. In this study, we have introduced a MEN 2A mutation (Cys634→Arg) and the unique… CONTINUE READING