Distinct binding and cellular properties of synthetic (+)- and (-)-discodermolides.

  title={Distinct binding and cellular properties of synthetic (+)- and (-)-discodermolides.},
  author={Deborah T Hung and Jacob Nerenberg and Stuart L. Schreiber},
  journal={Chemistry & biology},
  volume={1 1},
BACKGROUND Cell permeable ligands of low molecular weight can be used to dissect complex cellular processes. During the past several years this approach has been particularly important in the study of intracellular signal transduction. Discodermolide, a marine natural product, appears to inhibit a signaling pathway in immune cells. The structure of natural discodermolide is known, but its absolute stereochemistry is not. We set out to make both enantiomers and to investigate their biological… CONTINUE READING