Distinct bacterial dissemination and disease outcome in mice subcutaneously infected with Borrelia burgdorferi in the midline of the back and the footpad.

@article{Motameni2005DistinctBD,
  title={Distinct bacterial dissemination and disease outcome in mice subcutaneously infected with Borrelia burgdorferi in the midline of the back and the footpad.},
  author={Amir-Reza T Motameni and Tonya C. Bates and Ignacio J. Juncadella and Cynthia C. Petty and Michael Nathan Hedrick and Juan Anguita},
  journal={FEMS immunology and medical microbiology},
  year={2005},
  volume={45 2},
  pages={
          279-84
        }
}
Subcutaneous inoculation of mice with Borrelia burgdorferi, the causative agent of Lyme disease, results in established infection and the development of acute arthritis and carditis, hallmarks of human disease. Because conflicting results may originate from the site of subcutaneous inoculation, we addressed the dissemination capacity of spirochetes injected in the shoulder region versus the footpad. Spirochetes inoculated in the footpad disseminated to a lesser extent to distant organs, such as… CONTINUE READING
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