Distinct antitumor properties of a type IV collagen domain derived from basement membrane.

@article{Maeshima2000DistinctAP,
  title={Distinct antitumor properties of a type IV collagen domain derived from basement membrane.},
  author={Yohei Maeshima and Pablo C. Colorado and Adriana Torre and Kathryn A Holthaus and James A Grunkemeyer and Mark B. Ericksen and Helmut Hopfer and Yijin Xiao and Isaac E Stillman and Raghu Kalluri},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 28},
  pages={21340-8}
}
Vascular basement membrane is an important structural component of blood vessels. During angiogenesis this membrane undergoes many alterations and these changes are speculated to influence the formation of new capillaries. Type IV collagen is a major component of vascular basement membrane, and recently we identified a fragment of type IV collagen alpha2 chain with specific anti-angiogenic properties (Kamphaus, G. D., Colorado, P. C., Panka, D. J., Hopfer, H., Ramchandran, R., Torre, A… CONTINUE READING
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