Distinct and synergistic roles of FcγRIIB deficiency and 129 strain-derived SLAM family proteins in the development of spontaneous germinal centers and autoimmunity.

@article{Soni2015DistinctAS,
  title={Distinct and synergistic roles of FcγRIIB deficiency and 129 strain-derived SLAM family proteins in the development of spontaneous germinal centers and autoimmunity.},
  author={Chetna Soni and Phillip P Domeier and Eric B. Wong and Shwetank and Tahsin N. Khan and Melinda J. Elias and Stephanie L. Schell and Aron E Lukacher and Timothy K. Cooper and Ziaur S M Rahman},
  journal={Journal of autoimmunity},
  year={2015},
  volume={63},
  pages={31-46}
}
The inhibitory IgG Fc receptor (FcγRIIB) deficiency and 129 strain-derived signaling lymphocyte activation molecules (129-SLAMs) are proposed to contribute to the lupus phenotype in FcγRIIB-deficient mice generated using 129 ES cells and backcrossed to C57BL/6 mice (B6.129.RIIBKO). In this study, we examine the individual contributions and the cellular mechanisms by which FcγRIIB deficiency and 129-derived SLAM family genes promote dysregulated spontaneous germinal center (Spt-GC) B cell and… CONTINUE READING
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