Distinct and specific functions of cGMP-dependent protein kinases.

@article{Lohmann1997DistinctAS,
  title={Distinct and specific functions of cGMP-dependent protein kinases.},
  author={S. Lohmann and A. Vaandrager and A. Smolenski and U. Walter and H. D. de Jonge},
  journal={Trends in biochemical sciences},
  year={1997},
  volume={22 8},
  pages={
          307-12
        }
}
cGMP-dependent protein kinases I and II conduct signals from widespread signaling systems. Whereas the type I kinase mediates numerous effects of natriuretic peptides and nitric oxide in cardiovascular cells, the type II kinase transduces signals from the Escherichia coli heat-stable enterotoxin, STa, and from the endogenous intestinal peptide, guanylin, stimulating Cl- conductance of the cystic fibrosis transmembrane conductance regulator (CFTR). Although the two kinases may be interchangeable… Expand
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