Distinct and shared transcriptomes are regulated by microphthalmia-associated transcription factor isoforms in mast cells.

@article{Shahlaee2007DistinctAS,
  title={Distinct and shared transcriptomes are regulated by microphthalmia-associated transcription factor isoforms in mast cells.},
  author={Amir H. Shahlaee and Stephanie M. Brandal and Youngae Lee and Chunfa Jie and Clifford M. Takemoto},
  journal={Journal of immunology},
  year={2007},
  volume={178 1},
  pages={378-88}
}
The Microphthalmia-associated transcription factor (Mitf) is an essential basic helix-loop-helix leucine zipper transcription factor for mast cell development. Mice deficient in Mitf harbor a severe mast cell deficiency, and Mitf-mutant mast cells cultured ex vivo display a number of functional defects. Therefore, an understanding of the genetic program regulated by Mitf may provide important insights into mast cell differentiation. Multiple, distinct isoforms of Mitf have been identified in a… CONTINUE READING

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