Distinct and separable roles for EZH2 in neurogenic astroglia

  title={Distinct and separable roles for EZH2 in neurogenic astroglia},
  author={William W. Hwang and Ryan D. Salinas and J J Siu and Kevin W Kelley and Ryan N. Delgado and Mercedes Francisca Paredes and Arturo Alvarez-Buylla and Michael C. Oldham and Daniel A. Lim},
The epigenetic mechanisms that enable specialized astrocytes to retain neurogenic competence throughout adult life are still poorly understood. Here we show that astrocytes that serve as neural stem cells (NSCs) in the adult mouse subventricular zone (SVZ) express the histone methyltransferase EZH2. This Polycomb repressive factor is required for neurogenesis independent of its role in SVZ NSC proliferation, as Ink4a/Arf-deficiency in Ezh2-deleted SVZ NSCs rescues cell proliferation, but… CONTINUE READING
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