Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome

@article{Heintzman2007DistinctAP,
  title={Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome},
  author={Nathaniel D. Heintzman and Rhona K. Stuart and Gary Chung Hon and Yutao Fu and Christina W. Ching and Ronald Hawkins and Leah Barrera and Sara Van Calcar and Chunxu Qu and Keith A. Ching and Wei Wang and Zhiping Weng and Roland Green and Gregory E. Crawford and Bing Ren},
  journal={Nature Genetics},
  year={2007},
  volume={39},
  pages={311-318}
}
Eukaryotic gene transcription is accompanied by acetylation and methylation of nucleosomes near promoters, but the locations and roles of histone modifications elsewhere in the genome remain unclear. We determined the chromatin modification states in high resolution along 30 Mb of the human genome and found that active promoters are marked by trimethylation of Lys4 of histone H3 (H3K4), whereas enhancers are marked by monomethylation, but not trimethylation, of H3K4. We developed computational… 
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