Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction.

@article{Sato2000DistinctAE,
  title={Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction.},
  author={Motohiko Sato and Hirofumi Suemori and Nobuhiko Hata and Masataka Asagiri and Kouetsu Ogasawara and Kazuwa Nakao and Tadashi Nakaya and Motoya Katsuki and Shinzaburo Noguchi and Nobuyuki Tanaka and Tomoyasu Taniguchi},
  journal={Immunity},
  year={2000},
  volume={13 4},
  pages={539-48}
}
Induction of the interferon (IFN)-alpha/beta gene transcription in virus-infected cells is an event central to innate immunity. Mice lacking the transcription factor IRF-3 are more vulnerable to virus infection. In embryonic fibroblasts, virus-induced IFN-alpha/beta gene expression levels are reduced and the spectrum of the IFN-alpha mRNA subspecies altered. Furthermore, cells additionally defective in IRF-7 expression totally fail to induce these genes in response to infections by any of the… CONTINUE READING
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