Distinct and Overlapping Roles for E2F Family Members in Transcription, Proliferation and Apoptosis.

Abstract

Since the discovery almost fifteen years ago that E2F transcription factors are key targets of the retinoblastoma protein (RB), studies of the E2F family have uncovered critical roles in the control of transcription, cell cycle and apoptosis. E2F proteins are encoded by at least eight genes, E2F1 through E2F8. While specific roles for individual E2Fs in… (More)

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